ERBB2 - erb-b2 receptor tyrosine kinase 2 Gene
Also Known as NEU; NGL; HER2; TKR1; CD340; HER-2; VSCN2; MLN 19; MLN-19; c-ERB2; c-ERB-2; HER-2/neu; p185(erbB2)
Species: Homo sapiens
About ERBB2
This gene has 22 transcripts (splice variants), 200 orthologues, 53 paralogues and is associated with 151 phenotypes. Ubiquitous expression in kidney (RPKM 34.7), skin (RPKM 30.2) and 24 other tissues.
Summary
This gene encodes a member of the epidermal growth factor (EGF) receptor family of Receptor Tyrosine Kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to Other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and Others that have not been fully characterized. [provided by RefSeq, Jul 2008]
ERBB2 Products (32)
| mRNA | Protein | Name |
|---|---|---|
| NM_001382801.1 | NP_001369730.1 | receptor tyrosine-protein kinase erbB-2 isoform w precursor |
| NM_001382795.1 | NP_001369724.1 | receptor tyrosine-protein kinase erbB-2 isoform q precursor |
| NM_001382797.1 | NP_001369726.1 | receptor tyrosine-protein kinase erbB-2 isoform s precursor |
| NM_001289938.2 | NP_001276867.1 | receptor tyrosine-protein kinase erbB-2 isoform e |
| NM_001382793.1 | NP_001369722.1 | receptor tyrosine-protein kinase erbB-2 isoform o precursor |
| NR_110535.2 | ||
| NM_001382804.1 | NP_001369733.1 | receptor tyrosine-protein kinase erbB-2 isoform z precursor |
| NM_001382799.1 | NP_001369728.1 | receptor tyrosine-protein kinase erbB-2 isoform u precursor |
| NM_001289937.2 | NP_001276866.1 | receptor tyrosine-protein kinase erbB-2 isoform d precursor |
| NM_001382800.1 | NP_001369729.1 | receptor tyrosine-protein kinase erbB-2 isoform v precursor |
| NM_001382796.1 | NP_001369725.1 | receptor tyrosine-protein kinase erbB-2 isoform r precursor |
| NM_001382788.1 | NP_001369717.1 | receptor tyrosine-protein kinase erbB-2 isoform j precursor |
| NM_001382784.1 | NP_001369713.1 | receptor tyrosine-protein kinase erbB-2 isoform f precursor |
| NM_001382790.1 | NP_001369719.1 | receptor tyrosine-protein kinase erbB-2 isoform l precursor |
| NM_001382782.1 | NP_001369711.1 | receptor tyrosine-protein kinase erbB-2 isoform b |
| NM_001382806.1 | NP_001369735.1 | receptor tyrosine-protein kinase erbB-2 isoform bb precursor |
| NM_001382785.1 | NP_001369714.1 | receptor tyrosine-protein kinase erbB-2 isoform g precursor |
| NM_001382803.1 | NP_001369732.1 | receptor tyrosine-protein kinase erbB-2 isoform y precursor |
| NM_001382798.1 | NP_001369727.1 | receptor tyrosine-protein kinase erbB-2 isoform t precursor |
| XM_047435590.1 | XP_047291546.1 | receptor tyrosine-protein kinase erbB-2 isoform X1 |
| NM_001382791.1 | NP_001369720.1 | receptor tyrosine-protein kinase erbB-2 isoform m precursor |
| NM_001382787.1 | NP_001369716.1 | receptor tyrosine-protein kinase erbB-2 isoform i precursor |
| NM_001382802.1 | NP_001369731.1 | receptor tyrosine-protein kinase erbB-2 isoform x precursor |
| NM_001382786.1 | NP_001369715.1 | receptor tyrosine-protein kinase erbB-2 isoform h precursor |
| NM_001005862.3 | NP_001005862.1 | receptor tyrosine-protein kinase erbB-2 isoform b |
| NM_001382789.1 | NP_001369718.1 | receptor tyrosine-protein kinase erbB-2 isoform k precursor |
| NM_001382805.1 | NP_001369734.1 | receptor tyrosine-protein kinase erbB-2 isoform aa precursor |
| NM_001382792.1 | NP_001369721.1 | receptor tyrosine-protein kinase erbB-2 isoform n precursor |
| NM_001382794.1 | NP_001369723.1 | receptor tyrosine-protein kinase erbB-2 isoform p precorsor precursor |
| NM_001289936.2 | NP_001276865.1 | receptor tyrosine-protein kinase erbB-2 isoform c |
| NM_004448.4 | NP_004439.2 | receptor tyrosine-protein kinase erbB-2 isoform a precursor |
| NM_001382783.1 | NP_001369712.1 | receptor tyrosine-protein kinase erbB-2 isoform b |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of ERBB3:ERBB2 complex |
IDA
IDA: Inferred from direct assay
|
12000754 | GOA |
| located in basolateral plasma membrane |
IDA
IDA: Inferred from direct assay
|
12646923 | GOA |
| located in endosome membrane |
IDA
IDA: Inferred from direct assay
|
16314522 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
16314522 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
20010870 | GOA |
| part of receptor complex |
IDA
IDA: Inferred from direct assay
|
7514177 | GOA |
ERBB2 Protein Structure
Recep_L_domain: Receptor L domain (22 - 142)
Furin-like: Furin-like cysteine rich region (160 - 313)
Recep_L_domain: Receptor L domain (336 - 455)
GF_recep_IV: Growth factor receptor domain IV (481 - 612)
Pkinase_Tyr: Protein tyrosine kinase (691 - 945)
- 0
- 200
- 400
- 600
- 800
- 1000
- 1225 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
receptor tyrosine-protein kinase erbB-2 |
|
|
ERBB2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
ERBB2 | P04626 | RASA1 | Homo sapiens | P20936 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | CACYBP | Homo sapiens | Q9HB71 | 31980649 | |
|
Intra
|
ERBB2 | P04626 | CACYBP | Homo sapiens | Q9HB71 | 25036637 | |
|
Intra
|
ERBB2 | P04626 | ANKS1A | Homo sapiens | Q92625 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | STIP1 | Homo sapiens | P31948 | 25036637 | |
|
Intra
|
ERBB2 | P04626 | STIP1 | Homo sapiens | P31948 | 31980649 | |
|
Intra
|
ERBB2 | P04626 | CUL5 | Homo sapiens | Q93034 | 19933325 | |
|
Intra
|
ERBB2 | P04626 | STAT1 | Homo sapiens | P42224 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | ABL2 | Homo sapiens | P42684 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | MEMO1 | Homo sapiens | Q9Y316 | 21840311 | |
|
Intra
|
ERBB2 | P04626 | SLA2 | Homo sapiens | Q9H6Q3 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | PTPRB | Homo sapiens | P23467 | 19167335 | |
|
Intra
|
ERBB2 | P04626 | PTPRC | Homo sapiens | P08575 | 19167335 | |
|
Intra
|
ERBB2 | P04626 | JAK1 | Homo sapiens | P23458 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | PTK6 | Homo sapiens | Q13882 | 20700126 | |
|
Intra
|
ERBB2 | P04626 | PTK6 | Homo sapiens | Q13882 | 18719096 | |
|
Intra
|
ERBB2 | P04626 | FGR | Homo sapiens | P09769 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | DOK1 | Homo sapiens | Q99704 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | PTPRJ | Homo sapiens | Q12913 | 19167335 | |
|
Intra
|
ERBB2 | P04626 | PTPRR | Homo sapiens | Q15256 | 28065597 | |
|
Intra
|
ERBB2 | P04626 | PTPN12 | Homo sapiens | Q05209 | 21376233 | |
|
Intra
|
ERBB2 | P04626 | PTPN12 | Homo sapiens | Q05209 | 19167335 | |
|
Intra
|
ERBB2 | P04626 | NRG1 | Homo sapiens | Q02297-7 | 7592681 | |
|
Intra
|
ERBB2 | P04626 | TLN1 | Homo sapiens | Q9Y490 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | RECK | Homo sapiens | O95980 | 21255571 | |
|
Intra
|
ERBB2 | P04626 | RECK | Homo sapiens | O95980 | 21255571 | |
|
Intra
|
ERBB2 | P04626 | LRIG1 | Homo sapiens | Q96JA1 | 23723069 | |
|
Intra
|
ERBB2 | P04626 | KPNB1 | Homo sapiens | Q14974 | 16314522 | |
|
Intra
|
ERBB2 | P04626 | KPNB1 | Homo sapiens | Q14974 | 16314522 | |
|
Intra
|
ERBB2 | P04626 | KPNB1 | Homo sapiens | Q14974 | 16314522 | |
|
Intra
|
ERBB2 | P04626 | MACROH2A1 | Homo sapiens | O75367 | 22589551 | |
|
Intra
|
ERBB2 | P04626 | MACROH2A1 | Homo sapiens | O75367 | 22589551 | |
|
Intra
|
ERBB2 | P04626 | MACROH2A1 | Homo sapiens | O75367 | 22589551 | |
|
Intra
|
ERBB2 | P04626 | ERRFI1 | Homo sapiens | Q9UJM3 | 24189400 | |
|
Intra
|
ERBB2 | P04626 | ERRFI1 | Homo sapiens | Q9UJM3 | 35384245 | |
|
Intra
|
ERBB2 | P04626 | CDC37 | Homo sapiens | Q16543 | 35384245 | |
|
Intra
|
ERBB2 | P04626 | CDC37 | Homo sapiens | Q16543 | 35384245 | |
|
Intra
|
ERBB2 | P04626 | CDC37 | Homo sapiens | Q16543 | 24189400 | |
|
Intra
|
ERBB2 | P04626 | HSP90AA1 | Homo sapiens | P07900 | 23995768 | |
|
Intra
|
ERBB2 | P04626 | HSP90AA1 | Homo sapiens | P07900 | 24189400 | |
|
Intra
|
ERBB2 | P04626 | HSP90AA1 | Homo sapiens | P07900 | 35384245 | |
|
Intra
|
ERBB2 | P04626 | HSP90AA1 | Homo sapiens | P07900 | 25036637 | |
|
Intra
|
ERBB2 | P04626 | HSP90AA1 | Homo sapiens | P07900 | 20558745 | |
|
Intra
|
ERBB2 | P04626 | EGFR | Homo sapiens | P00533 | 16843263 | |
|
Intra
|
ERBB2 | P04626 | EGFR | Homo sapiens | P00533 | 16843263 | |
|
Intra
|
ERBB2 | P04626 | EGFR | Homo sapiens | P00533 | 23866081 | |
|
Intra
|
ERBB2 | P04626 | EGFR | Homo sapiens | P00533 | 16516204 | |
|
Intra
|
ERBB2 | P04626 | EGFR | Homo sapiens | P00533 | 21203579 | |
|
Intra
|
ERBB2 | P04626 | EGFR | Homo sapiens | P00533 | 24189400 | |
|
Intra
|
ERBB2 | P04626 | IQGAP1 | Homo sapiens | P46940 | 21724847 | |
|
Intra
|
ERBB2 | P04626 | IQGAP1 | Homo sapiens | P46940 | 21724847 | |
|
Intra
|
ERBB2 | P04626 | EEA1 | Homo sapiens | Q15075 | 16314522 | |
|
Intra
|
ERBB2 | P04626 | EEA1 | Homo sapiens | Q15075 | 16314522 | |
|
Intra
|
ERBB2 | P04626 | EEA1 | Homo sapiens | Q15075 | 16314522 | |
|
Intra
|
ERBB2 | P04626 | PIK3R2 | Homo sapiens | O00459 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | PIK3R2 | Homo sapiens | O00459 | 35384245 | |
|
Intra
|
ERBB2 | P04626 | PIK3R2 | Homo sapiens | O00459 | 16729043 | |
|
Intra
|
ERBB2 | P04626 | HSP90AB1 | Homo sapiens | P08238 | 24189400 | |
|
Intra
|
ERBB2 | P04626 | HSP90AB1 | Homo sapiens | P08238 | 22939624 | |
|
Intra
|
ERBB2 | P04626 | HSP90AB1 | Homo sapiens | P08238 | 35384245 | |
|
Intra
|
ERBB2 | P04626 | ACTB | Homo sapiens | P60709 | 21555369 | |
|
Intra
|
ERBB2 | P04626 | ACTB | Homo sapiens | P60709 | 21555369 | |
|
Intra
|
ERBB2 | P04626 | HSPA5 | Homo sapiens | P11021 | 24189400 | |
|
Intra
|
ERBB2 | P04626 | HSPA5 | Homo sapiens | P11021 | 35384245 | |
|
Intra
|
ERBB2 | P04626 | HSPA5 | Homo sapiens | P11021 | 31980649 | |
|
Intra
|
ERBB2 | P04626 | XPO1 | Homo sapiens | O14980 | 16314522 | |
|
Intra
|
ERBB2 | P04626 | XPO1 | Homo sapiens | O14980 | 35384245 | |
|
Intra
|
ERBB2 | P04626 | YWHAE | Homo sapiens | P62258 | 36931259 | |
|
Intra
|
ERBB2 | P04626 | HSP90B1 | Homo sapiens | P14625 | 23995768 | |
|
Intra
|
ERBB2 | P04626 | POLR1A | Homo sapiens | O95602 | 21555369 | |
|
Intra
|
ERBB2 | P04626 | POLR1A | Homo sapiens | O95602 | 21555369 | |
|
Intra
|
ERBB2 | P04626 | POLR1A | Homo sapiens | O95602 | 21555369 | |
|
Intra
|
ERBB2 | P04626 | GRB2 | Homo sapiens | P62993 | 24658140 | |
|
Intra
|
ERBB2 | P04626 | GRB2 | Homo sapiens | P62993 | 31980649 | |
|
Intra
|
ERBB2 | P04626 | GRB2 | Homo sapiens | P62993 | 35384245 | |
|
Intra
|
ERBB2 | P04626 | GRB2 | Homo sapiens | P62993 | 21278786 | |
|
Intra
|
ERBB2 | P04626 | GRB2 | Homo sapiens | P62993 | 16729043 | |
|
Intra
|
ERBB2 | P04626 | GRB2 | Homo sapiens | P62993 | 24189400 | |
|
Intra
|
ERBB2 | P04626 | GRB2 | Homo sapiens | P62993 | 35384245 | |
|
Intra
|
ERBB2 | P04626 | PTPRK | Homo sapiens | Q15262 | 19167335 | |
|
Intra
|
ERBB2 | P04626 | SH2D2A | Homo sapiens | Q9NP31 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | FYN | Homo sapiens | P06241 | 24815698 | |
|
Intra
|
ERBB2 | P04626 | IRS1 | Homo sapiens | P35568 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | STAT3 | Homo sapiens | P40763 | 11940572 | |
|
Intra
|
ERBB2 | P04626 | STAT3 | Homo sapiens | P40763 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | STAT3 | Homo sapiens | P40763 | 19372587 | |
|
Intra
|
ERBB2 | P04626 | STAT3 | Homo sapiens | P40763 | 20876300 | |
|
Intra
|
ERBB2 | P04626 | STAT3 | Homo sapiens | P40763 | 20876300 | |
|
Intra
|
ERBB2 | P04626 | EFNB1 | Homo sapiens | P98172 | 22279592 | |
|
Intra
|
ERBB2 | P04626 | EFNB1 | Homo sapiens | P98172 | 22279592 | |
|
Intra
|
ERBB2 | P04626 | PLCG2 | Homo sapiens | P16885 | 25241761 | |
|
Intra
|
ERBB2 | P04626 | CISH | Homo sapiens | Q9NSE2 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | SRC | Homo sapiens | P12931 | 11940572 | |
|
Intra
|
ERBB2 | P04626 | SRC | Homo sapiens | P12931 | 21075308 | |
|
Intra
|
ERBB2 | P04626 | SRC | Homo sapiens | P12931 | 19372587 | |
|
Intra
|
ERBB2 | P04626 | ERBB3 | Homo sapiens | P21860 | 21075308 | |
|
Intra
|
ERBB2 | P04626 | ERBB3 | Homo sapiens | P21860 | 21278786 | |
|
Intra
|
ERBB2 | P04626 | ERBB3 | Homo sapiens | P21860 | 21203579 | |
|
Intra
|
ERBB2 | P04626 | ERBB3 | Homo sapiens | P21860 | 23436906 | |
|
Intra
|
ERBB2 | P04626 | ERBB3 | Homo sapiens | P21860 | 16843263 | |
|
Intra
|
ERBB2 | P04626 | ERBB3 | Homo sapiens | P21860 | 23680147 | |
|
Intra
|
ERBB2 | P04626 | ERBB3 | Homo sapiens | P21860 | 7592681 | |
|
Intra
|
ERBB2 | P04626 | ERBB3 | Homo sapiens | P21860 | 22733765 | |
|
Intra
|
ERBB2 | P04626 | ERBB3 | Homo sapiens | P21860 | 20227043 | |
|
Intra
|
ERBB2 | P04626 | ERBB3 | Homo sapiens | P21860 | 23680147 | |
|
Intra
|
ERBB2 | P04626 | ERBB3 | Homo sapiens | P21860 | 22806884 | |
|
Intra
|
ERBB2 | P04626 | ERBB3 | Homo sapiens | P21860 | 23866081 | |
|
Intra
|
ERBB2 | P04626 | ERBB3 | Homo sapiens | P21860 | 17426253 | |
|
Intra
|
ERBB2 | P04626 | PIK3C2B | Homo sapiens | O00750 | 10805725 | |
|
Intra
|
ERBB2 | P04626 | PIK3C2B | Homo sapiens | O00750 | 10805725 | |
|
Intra
|
ERBB2 | P04626 | DOK4 | Homo sapiens | Q8TEW6 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | BCAR3 | Homo sapiens | O75815 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | MAPK8IP2 | Homo sapiens | Q13387 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | PTPRO | Homo sapiens | Q16827 | 19167335 | |
|
Intra
|
ERBB2 | P04626 | SHC2 | Homo sapiens | P98077 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | GRAP2 | Homo sapiens | O75791 | 25241761 | |
|
Intra
|
ERBB2 | P04626 | MATK | Homo sapiens | P42679 | 12122014 | |
|
Intra
|
ERBB2 | P04626 | SYK | Homo sapiens | P43405 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | MAPK8IP1 | Homo sapiens | Q9UQF2 | 31980649 | |
|
Intra
|
ERBB2 | P04626 | MAPK8IP1 | Homo sapiens | Q9UQF2 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | VAV1 | Homo sapiens | Q96D37 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | CLNK | Homo sapiens | Q7Z7G1 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | SHC1 | Homo sapiens | P29353 | 16729043 | |
|
Intra
|
ERBB2 | P04626 | SHC1 | Homo sapiens | P29353 | 16843263 | |
|
Intra
|
ERBB2 | P04626 | SHC1 | Homo sapiens | P29353 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | SHC1 | Homo sapiens | P29353 | 35384245 | |
|
Intra
|
ERBB2 | P04626 | PLCG1 | Homo sapiens | P19174 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | PIK3R1 | Homo sapiens | P27986 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | PIK3R1 | Homo sapiens | P27986 | 16843263 | |
|
Intra
|
ERBB2 | P04626 | PIK3R1 | Homo sapiens | P27986 | 35384245 | |
|
Intra
|
ERBB2 | P04626 | PIK3R1 | Homo sapiens | P27986 | 21075308 | |
|
Intra
|
ERBB2 | P04626 | PIK3R3 | Homo sapiens | Q92569 | 35384245 | |
|
Intra
|
ERBB2 | P04626 | PIK3R3 | Homo sapiens | Q92569 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | ERBB4 | Homo sapiens | Q15303 | 16767099 | |
|
Intra
|
ERBB2 | P04626 | ERBB4 | Homo sapiens | Q15303 | 10572067 | |
|
Intra
|
ERBB2 | P04626 | ERBB4 | Homo sapiens | Q15303 | 21203579 | |
|
Intra
|
ERBB2 | P04626 | ERBB4 | Homo sapiens | Q15303 | 24557338 | |
|
Intra
|
ERBB2 | P04626 | ERBB4 | Homo sapiens | Q15303 | 35384245 | |
|
Intra
|
ERBB2 | P04626 | APBB1 | Homo sapiens | O00213 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | CRKL | Homo sapiens | P46109 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | TNS2 | Homo sapiens | Q63HR2 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | ITK | Homo sapiens | Q08881 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | GRB7 | Homo sapiens | Q14451 | 12061724 | |
|
Intra
|
ERBB2 | P04626 | GRB7 | Homo sapiens | Q14451 | 16273093 | |
|
Intra
|
ERBB2 | P04626 | GRB7 | Homo sapiens | Q14451 | 9079677 | |
|
Intra
|
ERBB2 | P04626 | RANBP2 | Homo sapiens | P49792 | 16314522 | |
|
Intra
|
ERBB2 | P04626 | RANBP2 | Homo sapiens | P49792 | 16314522 |
Recombinant ERBB2 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70254 | HER2/CD340 Protein, Human (HEK293, His) | P04626-1 (T23-T652) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70759 | HER2/CD340 Protein, Human (HEK293, Fc) | P04626-1 (T23-T652) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72374 | HER2/CD340 Protein, Human (Biotinylated, HEK293, Fc-Avi) | P04626-1 (T23-T652) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P73094 | HER2/CD340 Protein, Human (HEK293) | P04626-1 (T23-T652) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P73095 | HER2/CD340 Protein, Human (Domain 4, HEK293, His) | P04626-1/NP_004439.2 (P489-C630) | ≥ 85%, as determined by reducing SDS-PAGE. |
| HY-P73931 | HER2/CD340 Protein, Human (Biotinylated, 173a.a, HEK293, His) | P04626-1 (T23-C195) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P77533 | HER2/CD340 Protein, Human (Biotinylated, HEK293, Fc) | P04626-1 (T23-T652) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P77535 | HER2/CD340 Protein, Human (Biotinylated, Domain 4, HEK293, His-Avi) | P04626-1 (P489-C630) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P78138 | HER2/CD340 Protein, Human (Biotinylated, HEK293, His-Avi) | P04626-1 (T23-T652) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P78451 | HER2/CD340 Protein, Human (HEK293, His-Avi) | P04626-1 (T23-T652) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P78652 | FITC-Labeled HER2/CD340 Protein, Human (HEK293, His) | P04626-1 (T23-T652) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P78679 | HER2/CD340 Protein, Human (S310F, HEK293, His) | P04626-1 (T23-T652, S310F) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P78680 | HER2/CD340 Protein, Human (S310Y, HEK293, His) | P04626-1 (T23-T652, S310Y) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P78882 | HER2/CD340 Protein, Human (Biotinylated, HEK293, His) | P04626-1 (T23-T652) | ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE. |
ERBB2 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80500 | C-erbB-2/HER2 Antibody (YA388) | WB, IHC-P, ICC/IF, FC, mIHC | Human |
| HY-P80658 | C-erbB-2/HER2 Antibody (YA771) | WB, IHC-F, IHC-P, ICC/IF | Human, Mouse, Rat |
| HY-P80658A | C-erbB-2/HER2 Antibody (YA771)(PBS only) | WB, IHC-F, IHC-P, ICC/IF | Human, Mouse, Rat |
| HY-P810657 | Phospho-HER2 / ErbB2 (Tyr1248) Antibody (YA9917) | WB, ICC/IF | Human |
| HY-P810658 | Phospho-HER2 / ErbB2 (Thr686) Antibody (YA9918) | WB, IP | Human, Mouse, Rat |
| HY-P810659 | Phospho-HER2 / ErbB2 (Tyr1139) Antibody (YA9919) | WB, ICC/IF, FC | Human |
| HY-P83761 | Phospho-C-erbB-2/HER2(Tyr1221/Tyr1222) Antibody | WB, IHC-P, IP, ELISA | Human, Mouse |
| HY-P83946 | C-erbB-2/HER2 Antibody (YA3643) | WB, IHC-P, FC, ELISA | Human, Mouse |
| HY-P83946A | C-erbB-2/HER2 Antibody (YA3643)(PBS only) | WB, IHC-P, FC, ELISA | Human |
| HY-P86166 | Phospho-C-erbB-2/HER2(Tyr1221/Tyr1222) Antibody (YA5858) | WB, ICC/IF, IP, ELISA | Human |
| HY-P86242 | C-erbB-2/HER2 Antibody (YA5934) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
| HY-P86719 | C-erbB-2/HER2 Antibody (YA6411) | WB, IHC-P, IHC-F, IF-Tissue | Human |
| HY-P86719A | C-erbB-2/HER2 Antibody (YA6411)(PBS only) | WB, IHC-P, IHC-F, IF-Tissue | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Anus Cancer |
|
|
| Intraductal Papilloma |
|
|
| Neurofibroma |
|
|
| Neuroblastoma |
|
|
| Mammary Paget'S Disease |
|
|
| Ampulla Of Vater Cancer |
|
|
| Thoracic Benign Neoplasm |
|
|
| Signet Ring Cell Adenocarcinoma |
|
|
| Breast Fibroadenosis |
|
|
| Gastric Cancer |
|
|
| Endocervical Carcinoma |
|
|
| Papilloma |
|
|
| Pre-Malignant Neoplasm |
|
|
| Leukemia |
|
|
| Infratentorial Cancer |
|
|
| Fallopian Tube Transitional Cell Carcinoma |
|
|
| Breast Abscess |
|
|
| Glioma Susceptibility 1 |
|
|
| Pancreatic Adenocarcinoma |
|
|
| Lipid-Rich Carcinoma |
|
|
| Skin Carcinoma |
|
|
| Sebaceous Adenocarcinoma |
|
|
| Uterine Body Mixed Cancer |
|
|
| Spinal Polio |
|
|
| Endometrial Serous Adenocarcinoma |
|
|
| Non-Proliferative Fibrocystic Change Of The Breast |
|
|
| Breast Papillary Carcinoma |
|
|
| Fallopian Tube Endometrioid Adenocarcinoma |
|
|
| Nipple Carcinoma |
|
|
| Squamous Cell Carcinoma |
|
|
| Amelogenesis Imperfecta |
|
|
| Apocrine Adenosis Of Breast |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Keratoconjunctivitis Sicca |
|
|
| Tubular Adenocarcinoma |
|
|
| Prostate Cancer |
|
|
| Bile Duct Cancer |
|
|
| Pylorus Cancer |
|
|
| Gallbladder Disease |
|
|
| Testicular Cancer |
|
|
| Bladder Cancer |
|
|
| Rectum Adenocarcinoma |
|
|
| Gestational Ovarian Choriocarcinoma |
|
|
| Triple-Receptor Negative Breast Cancer |
|
|
| Cribriform Carcinoma |
|
|
| Cowden Syndrome 1 |
|
|
| Hypertrophy Of Breast |
|
|
| Glycogen-Rich Carcinoma |
|
|
| Leukocyte Disease |
|
|
| Sebaceous Breast Carcinoma |
|
|
| Biliary Tract Cancer |
|
|
| Paget Disease, Extramammary |
|
|
| Vulva Basal Cell Carcinoma |
|
|
| Good Syndrome |
|
|
| Pancreatic Cancer |
|
|
| Breast Mucinous Carcinoma |
|
|
| Serous Cystadenocarcinoma |
|
|
| Salivary Gland Disease |
|
|
| Chromophobe Renal Cell Carcinoma |
|
|
| Gastric Diffuse Adenocarcinoma |
|
|
| Gastroesophageal Adenocarcinoma |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Skin Melanoma |
|
|
| Vulva Cancer |
|
|
| Diarrhea |
|
|
| Thyroid Gland Cancer |
|
|
| Diffuse Idiopathic Skeletal Hyperostosis |
|
|
| Colorectal Cancer |
|
|
| Li-Fraumeni Syndrome |
|
|
| Papillary Adenocarcinoma |
|
|
| Meningioma, Familial |
|
|
| Transitional Cell Carcinoma |
|
|
| Thoracic Cancer |
|
|
| Linitis Plastica |
|
|
| Ovarian Carcinosarcoma |
|
|
| Eccrine Mixed Tumor Of Skin |
|
|
| Hair Disease |
|
|
| Breast Ductal Carcinoma |
|
|
| Lymphangitis |
|
|
| Glioblastoma |
|
|
| Lipid-Rich Breast Carcinoma |
|
|
| Dilated Cardiomyopathy |
|
|
| Ovarian Clear Cell Cystadenocarcinoma |
|
|
| Wilms Tumor 1 |
|
|
| Breast Lobular Carcinoma |
|
|
| Lung Cancer |
|
|
| Breast Cancer |
|
|
| Luminal Breast Carcinoma B |
|
|
| Bladder Exstrophy |
|
|
| Her2-Receptor Negative Breast Cancer |
|
|
| Bile Duct Adenocarcinoma |
|
|
| Estrogen-Receptor Positive Breast Cancer |
|
|
| Endometrial Cancer |
|
|
| Lynch Syndrome |
|
|
| Scirrhous Adenocarcinoma |
|
|
| Sphingolipidosis |
|
|
| Gastrointestinal Stromal Tumor |
|
|
| Breast Disease |
|
|
| Thymus Cancer |
|
|
| Oncocytic Breast Carcinoma |
|
|
| Adenosquamous Carcinoma |
|
|
| Exudative Vitreoretinopathy 2, X-Linked |
|
|
| Uterine Corpus Cancer |
|
|
| Duodenum Cancer |
|
|
| Bronchus Cancer |
|
|
| Hereditary Breast Ovarian Cancer Syndrome |
|
|
| Cholangiocarcinoma |
|
|
| Retinitis Pigmentosa |
|
|
| Breast Squamous Cell Carcinoma |
|
|
| Apocrine Adenocarcinoma |
|
|
| Paraneoplastic Cerebellar Degeneration |
|
|
| Ovary Adenocarcinoma |
|
|
| Melanoma, Uveal |
|
|
| Bladder Urothelial Carcinoma |
|
|
| Gynecomastia |
|
|
| Skin Disease |
|
|
| Teeth Hard Tissue Disease |
|
|
| Cardia Cancer |
|
|
| Carcinosarcoma |
|
|
| Breast Secretory Carcinoma |
|
|
| Peripheral Nervous System Neoplasm |
|
|
| Breast Malignant Phyllodes Tumor |
|
|
| Breast Juvenile Papillomatosis |
|
|
| Sporadic Breast Cancer |
|
|
| Ovarian Clear Cell Malignant Adenofibroma |
|
|
| Fallopian Tube Carcinoma |
|
|
| Adenoid Cystic Carcinoma |
|
|
| Breast Fibroadenoma |
|
|
| Ptosis |
|
|
| Bilateral Breast Cancer |
|
|
| Prolactinoma |
|
|
| Breast Metaplastic Carcinoma |
|
|
| Breast Adenoid Cystic Carcinoma |
|
|
| Esophagus Small Cell Carcinoma |
|
|
| Ovarian Serous Cystadenocarcinoma |
|
|
| Vulva Adenocarcinoma |
|
|
| Inflammatory Breast Carcinoma |
|
|
| Pheochromocytoma |
|
|
| Short Syndrome |
|
|
| Childhood Osteosarcoma |
|
|
| Microglandular Adenosis |
|
|
| Breast Benign Neoplasm |
|
|
| Gaucher Disease, Type Ii |
|
|
| Mucinous Adenocarcinoma |
|
|
| Nervous System Disease |
|
|
| Premature Menopause |
|
|
| Gaucher'S Disease |
|
|
| Colonic Benign Neoplasm |
|
|
| Breast Carcinoma In Situ |
|
|
| Lung Non-Squamous Non-Small Cell Carcinoma |
|
|
| Ovarian Cystadenocarcinoma |
|
|
| Ductal Carcinoma In Situ |
|
|
| Her2-Receptor Positive Breast Cancer |
|
|
| Wallerian Degeneration |
|
|
| Leukemia, Chronic Myeloid |
|
|
| Suppression Of Tumorigenicity 12 |
|
|
| Mixed Cell Type Cancer |
|
|
| Colorectal Adenocarcinoma |
|
|
| Medulloblastoma |
|
|
| Pancreatic Ductal Carcinoma |
|
|
| Intracystic Papillary Adenoma |
|
|
| Hirschsprung Disease 1 |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Cervical Cancer |
|
|
| Ovarian Disease |
|
|
| Microinvasive Gastric Cancer |
|
|
| Large Cell Carcinoma |
|
|
| Uterine Carcinosarcoma |
|
|
| Bulbospinal Polio |
|
|
| Breast Osteosarcoma |
|
|
| Oropharynx Cancer |
|
|
| Synchronous Bilateral Breast Carcinoma |
|
|
| Sweat Gland Disease |
|
|
| Peritoneum Cancer |
|
|
| Female Breast Cancer |
|
|
| Intraductal Breast Benign Neoplasm |
|
|
| Ovary Epithelial Cancer |
|
|
| Localized Osteosarcoma |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| In Situ Carcinoma |
|
|
| Lobular Neoplasia |
|
|
| Gallbladder Cancer |
|
|
| Exanthem |
|
|
| Estrogen-Receptor Negative Breast Cancer |
|
|
| Human Papillomavirus Infectious Disease |
|
|
| Ovarian Cancer |
|
|
| Papillary Serous Adenocarcinoma |
|
|
| Skin Squamous Cell Carcinoma |
|
|
| Cervix Carcinoma |
|
|
| Progesterone-Receptor Negative Breast Cancer |
|
|
| Ethmoid Sinus Adenocarcinoma |
|
|
| Blood Platelet Disease |
|
|
| Female Reproductive Endometrioid Cancer |
|
|
| Salivary Gland Carcinoma |
|
|
| Acute Promyelocytic Leukemia |
|
|
| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
|
|
| Eye Disease |
|
|
| Barrett Esophagus |
|
|
| Breast Intraductal Papillomatosis |
|
|
| Sensorineural Hearing Loss |
|
|
| Breast Sarcoma |
|
|
| Pleomorphic Adenoma |
|
|
| Pleomorphic Adenoma Carcinoma |
|
|
| Luminal Breast Carcinoma A |
|
|
| Renal Cell Carcinoma, Papillary, 1 |
|
|
| Leukemia, Acute Myeloid |
|
|
| Gastroesophageal Junction Adenocarcinoma |
|
|
| Endocervical Adenocarcinoma |
|
|
| Breast Adenocarcinoma |
|
|
| Esophageal Cancer |
|
|
| Esophageal Adenosquamous Carcinoma |
|
|
| Mixed Epithelial Tumor Of Ovary |
|
|
| Tooth Disease |
|
|
| Diffuse Gastric Cancer |
|
|
| Papillary Carcinoma |
|
|
| Amelogenesis Imperfecta, Type Ig |
|
|
| Hypoganglionosis |
|
|
| Brain Glioma |
|
|
| Gliosarcoma |
|
|
| Sweat Gland Cancer |
|
|
| Cowden Syndrome |
|
|
| Thymus Gland Disease |
|
|
| Basal Cell Carcinoma |
|
|
| Barrett'S Adenocarcinoma |
|
|
| Progesterone-Receptor Positive Breast Cancer |
|
|
| Adenosarcoma |
|
|
| Mantle Cell Lymphoma |
|
|
| Glycogen-Rich Clear Cell Breast Carcinoma |
|
|
| Teratoma |
|
|
| Tonsil Cancer |
|
|
| Esophagus Adenocarcinoma |
|
|
| Diffuse Gastric And Lobular Breast Cancer Syndrome |
|
|
| Small Intestine Cancer |
|
|
| Thrombocytopenia |
|
|
| Adenocarcinoma |
|
|
| Charcot-Marie-Tooth Disease |
|
|
| Gallbladder Adenocarcinoma |
|
|
| Parotid Gland Cancer |
|
|
| Breast Cystic Hypersecretory Carcinoma |
|
|
| Peripheral Nervous System Disease |
|
|
| Vulval Paget'S Disease |
|
|
| Gastric Adenocarcinoma |
|
|
| Fallopian Tube Mucinous Adenocarcinoma |
|
|
| Rhabdomyosarcoma |
|
|
| Keratoconjunctivitis |
|
|
| Fallopian Tube Disease |
|
|
| Visceral Neuropathy, Familial, 2, Autosomal Recessive |
|
|
| Comedo Carcinoma |
|
|
| Vulvar Disease |
|
|
| Apocrine Sweat Gland Neoplasm |
|
|
| Laryngeal Mucoepidermoid Carcinoma |
|
|
| Breast Mucinous Cystadenocarcinoma |
|
|
| Autonomic Nervous System Neoplasm |
|
|
| Bone Cancer |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | ERBB2 | VGNC | VGNC:40436 |
| Felis catus | ERBB2 | VGNC | VGNC:61927 |
| Rattus norvegicus | ERBB2 | RGD | RGD:2561 |
| Mus musculus | ERBB2 | MGD | MGI:95410 |
| Macaca mulatta | ERBB2 | VGNC | VGNC:72252 |
| Bos taurus | ERBB2 | VGNC | VGNC:28563 |
| Others | ERBB2 | NCBI |